An Isle of Wight school principal said an Ofsted inspection “broke the camel’s back” and forced her to quit her job.
Sarah Hussey said she suffered a series of heart emergencies brought on by stress.
Northwood Primary School’s principal believes they were set off by Ofsted inspectors who visited the school.
It comes after Berkshire CEO Ruth Perry took her own life following an inspection. Ofsted declined to comment.
Inspectors visited Miss Hussey’s school on the same day that Mrs Perry had an inspection at Caversham Primary in Reading.
While Northwood Primary received a good rating on inspection, the 52-year-old principal said the stress led to a series of events that led to her deciding to resign.
She said: “I didn’t feel like they came with an open mind, it felt quite personal that they were trying to get a hold of me and what I said wasn’t necessarily true.
“I worked 55-60 hours a week on a regular basis, I could tell you inside and out about this school and about every kid in this school and every staff member, but I felt I had to prove it.
“It didn’t feel like they were coming to improve the school, it just felt like it was a whole different agenda.”
A week after the inspection, Miss Hussey was on a school trip to Osbourne House with a group of first graders.
When she felt tingling in her arm on the drive home, she blamed it on the student who had fallen asleep on her arm, but then noticed pain in her chest.
“Within a few days I was in the hospital saying I had a series of heart problems that would lead to something bigger if I wasn’t treated right away,” she said.
Miss Hussey acknowledged she suffers from other pressures and ongoing health issues, but “Ofsted was the straw that broke the camel’s back”.
She said: “After 25 years in training my main feeling for weeks after being bad was that I had failed, that I had let the community down – and with a good Ofsted at that.
“I can’t even imagine what it must have been like for poor Ruth Perry and for her family and her school community. Ofsted does not support schools and we need to change something.”
Ruth Perry’s sister, Professor Julia Waters, will address members of the National Association for Head Teachers Union (NAHT) on Saturday.
She is calling for “radical reform” of Ofsted and is expected to say her sister’s legacy “must be that no other family has to go through the pain of losing someone after an inspection”.
Keep following BBC South Facebook, Twitteror Instagram. Submit your story ideas to south.newsonline@bbc.co.uk.
Add Comment